Effect of histaminergic drugs on footshock-induced aggressive behaviour in rats
| Autor: | Arunava Ray, Parantapa Sen, Krishna K. Sharma |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Pyridines Mepyramine Pharmacology Inhibitory postsynaptic potential chemistry.chemical_compound Catecholamines Internal medicine medicine Animals Humans Receptors Histamine H2 Receptors Histamine H1 Cimetidine Receptor Electroshock 2-Pyridylethylamine Aggression Methylhistamines Rats Endocrinology chemistry Receptors Histamine medicine.symptom 4-Methylhistamine Histamine medicine.drug |
| Zdroj: | European Journal of Pharmacology. 73:217-219 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(81)90094-7 |
| Popis: | Histamine and 2-pyridylethylamine decreased and 4-methylhistamine increased footshock-induced aggression after their intracerebroventricular administration to rats. Mepyramine and cimetidine had no effect on the fighting response but blocked the effects of the respective agonists. Histamine when given after mepyramine increased and after cimetidine decreased the fighting score, this decrease being more than that with histamine alone. It is inferred that central H 1 -receptors are inhibitory and H 2 -receptors facilitatory in footshock aggression and that this is independent of catechholaminergic mechanisms. |
| Databáze: | OpenAIRE |
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