Building a Harmonized Datamart by Integrating Cross-Institutional Systems of Clinical, Outcome, and Genomic Data: The Pediatric Patient Informatics Platform (
| Autor: | Mark Auclair, Wendy B. London, John Orechia, Vani Kuragayala, Hasan Al-Sayegh, Hugh Cruse, Chandini Bandaru, Clement Ma, Dongjing Guo, Jonathan Bickel, Ron Beaudoin, Madhumitha Sridharan, Anran Li, Dana Milne |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Databases Factual business.industry Information Dissemination Genomic data MEDLINE Cancer Information Storage and Retrieval General Medicine Genomics medicine.disease Outcome (game theory) 03 medical and health sciences Pediatric patient 030104 developmental biology 0302 clinical medicine Blood Disorder 030220 oncology & carcinogenesis Informatics Medicine Humans Medical physics business Child |
| Zdroj: | JCO clinical cancer informatics. 5 |
| ISSN: | 2473-4276 |
| Popis: | PURPOSE Siloed electronic medical data limits utility and accessibility. At the Dana-Farber/Boston Children's Cancer and Blood Disorders Center, cross-institutional data were inconsistent and difficult to access. To unify data for clinical operations, administration, and research, we developed the Pediatric Patient Informatics Platform ( PPIP), an integrated datamart harmonizing multiple source systems across two institutions into a common technology. PATIENTS AND METHODS Starting in 2009, user requirements were gathered and data sources were prioritized. Project teams, including biostatisticians, database developers, and an external contractor, were formed. Read-access to source systems was established. The 3-layer PPIP architecture was developed: STAGING, a near-exact copy of source data; INTEGRATION, where data were reorganized into domains; and, CONSUMPTION, where data were optimized for rapid retrieval. The diverse systems were integrated into a common IBM Netezza technology. Data filters were defined to accurately capture the Center's patients, and derived data items were created for harmonization across sources. An interactive online query tool, PPIP360, was developed using Microstrategy Analytics. RESULTS Driven by scientific objectives, the PPIP datamart was created, including 33,674 patients, 2,983 protocols, and 3.6 million patient visits from 14 source databases, 164 source tables, and 2,622 source data items. The PPIP360 has 605 data items and 33 metrics across 11 reports and dashboards. Dana-Farber and Boston Children's established a legal data-sharing agreement. The PPIP has supported hundreds of faculty, staff, and projects, including planning clinical trials and informing strategic planning. CONCLUSION The PPIP has successfully harmonized and integrated diagnostic, demographic, laboratory, treatment, clinical outcome, pathology, transplant, meta-protocol, and –omics data, for efficient, daily operational and research activities at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, and future external sharing. |
| Databáze: | OpenAIRE |
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