Direct Synthesis of Hydroquinones from Quinones through Sequential and Continuous‐Flow Hydrogenation‐Derivatization Using Heterogeneous Au–Pt Nanoparticles as Catalysts

Autor:	Hiroyuki Miyamura, Fumiya Tobita, Shū Kobayashi, Aya Suzuki
Rok vydání:	2019
Předmět:	010405 organic chemistry Continuous flow General Chemistry General Medicine 010402 general chemistry 01 natural sciences Decomposition Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Polysilane Reactivity (chemistry) Pt nanoparticles Selectivity Derivatization
Zdroj:	Angewandte Chemie. 131:9318-9322
ISSN:	1521-3757 0044-8249
DOI:	10.1002/ange.201904159
Popis:	Pt-Au bimetallic nanoparticle catalysts immobilized on dimethyl polysilane (Pt-Au/(DMPSi-Al2 O3 )) have been developed for selective hydrogenation of quinones to hydroquinones. High reactivity, selectivity, and robustness of the catalysts were confirmed under continuous-flow conditions. Various direct derivatizations of quinones, such as methylation, acetylation, trifluoromethanesulfonylation, methacrylation, and benzoylation were successfully performed under sequential and continuous-flow conditions to afford the desired products in good to excellent yields. Especially, air-sensitive hydroquinones, such as anthrahydroquinones and naphthohydroquinones, could be successfully generated and derivatized under closed sequential and continuous-flow conditions without decomposition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aab9da189f4b9ed938e338a9011b30 https://doi.org/10.1002/ange.201904159 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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