Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia
| Autor: | Koji Ioku, Masanobu Kamitakahara, Tohru Ikeda, Yoshinori Gonda, Hisashi Kurosawa, Izumi Asahina, Takatoshi Okuda, Ikuho Yonezawa, Teruhito Okumura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
β tricalcium phosphate
Materials science Healing of bone defect Regeneration (biology) General Chemistry Rat tibia Condensed Matter Physics Phosphate Bone tissue chemistry.chemical_compound medicine.anatomical_structure Hydrothermal route chemistry Alkaline phosphatase Beta-tricalcium phosphate Materials Chemistry Ceramics and Composites medicine Bone substitute Implant Bone marrow Biomedical engineering |
| Zdroj: | Journal of the Ceramic Society of Japan. 119(1386):101-104 |
| ISSN: | 1882-0743 |
| Popis: | Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow. Journal of the Ceramic Society of Japan, 119(1386), pp.101-104; 2011 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|