Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: A semi-empirical investigation
| Autor: | John F. Honek, Christine E. Hand |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Stereochemistry
Inositol Phosphates Organic Chemistry Clinical Biochemistry Inorganic chemistry Pharmaceutical Science Biological Transport Phosphate Models Biological Biochemistry Pyrophosphate Phosphates Diphosphates Serine chemistry.chemical_compound chemistry Drug Discovery Animals Molecular Medicine Phosphorylation Inositol Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 17:183-188 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2006.09.066 |
| Popis: | A novel phosphate transfer process involving the non-enzymatic transfer of a phosphate group from inositol pyrophosphates to serine residues in proteins has been recently reported. Semi-empirical calculations at the PM3/SM5.2 level were undertaken to explore the effect of inositol pyrophosphate structure and overall charge on the thermodynamics of this phosphate transfer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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