Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment

Autor: Elaine C. Brown, Walter E. Kaufmann, David R Hessl, Scott S. Hall, Elizabeth Berry-Kravis, Stephanie M. Sansone, Keith F. Widaman, Ave M. Lachiewicz, Allan L. Reiss, Amy A. Lightbody
Rok vydání: 2011
Předmět:
Male
Outcome Assessment
Psychometrics
Autism
DNA Mutational Analysis
Personality Assessment
Fragile X Mental Retardation Protein
FMR1 gene
Intellectual disability
Outcome Assessment
Health Care
Developmental and Educational Psychology
Child
Pediatric
Statistical
Confirmatory factor analysis
Checklist
Fragile X syndrome
Mental Health
Child
Preschool
Female
Factor analysis
Personality Assessment Inventory
medicine.symptom
Psychology
Social Adjustment
Clinical psychology
medicine.medical_specialty
congenital
hereditary
and neonatal diseases and abnormalities
Adolescent
Intellectual and Developmental Disabilities (IDD)
Developmental & Child Psychology
Child Behavior Disorders
Rating scale
Irritability
Article
Education
Young Adult
Social avoidance
Rare Diseases
Intellectual Disability
Behavioral and Social Science
medicine
Humans
Preschool
Psychiatry
Psychotropic Drugs
Psychology and Cognitive Sciences
Reproducibility of Results
medicine.disease
Brain Disorders
Health Care
Stereotypy (non-human)
Fragile X Syndrome
Factor Analysis
Statistical
Zdroj: Journal of autism and developmental disorders, vol 42, iss 7
ISSN: 1573-3432
Popis: Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.
Databáze: OpenAIRE
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