Complete genome sequencing and evolutionary analysis of hepatitis C virus subtype 6a, including strains from Guangdong Province, China

Autor: Ru Xu, Hao Wang, Jieting Huang, Min Wang, Qiao Liao, Zhengang Shan, Huishan Zhong, Xia Rong, Yongshui Fu
Rok vydání: 2021
Předmět:
Zdroj: Archives of Virology
ISSN: 1432-8798
Popis: We performed an evolutionary analysis using whole genome sequence isolates of hepatitis C virus (HCV) 6a from Guangdong Province and reference sequences from various countries. Less than 5% of the HCV genome was found to be under positive selection. The E1 and E2 proteins had the highest proportion of positively selected sites both within and outside of CD8 T cell epitopes in all of the strains. Regions corresponding to CD8 T cell epitopes were under negative selection except in the isolates from Guangdong. Furthermore, we found evidence of three introductions of the virus into Guangdong from Vietnam and other Southeast Asian countries. Thus, this study provides information about the transmission of HCV 6a by comparison of full-length sequences, indicating the impact of selective constraints in Guangdong and across China. Supplementary Information The online version contains supplementary material available at 10.1007/s00705-021-05358-7.
Databáze: OpenAIRE