Immune-based therapies in pancreatic and colorectal cancers and biomarkers of responsiveness
| Autor: | Giovanni Francesco Castino, Federica Marchesi, Giuseppe Di Caro, Nina Cortese, Fabio Grizzi, Maurizio Chiriva-Internati, Francesca Bergomas |
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| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Tumor microenvironment business.industry Immune microenvironment medicine.medical_treatment Cancer Immunotherapy medicine.disease Pancreatic Neoplasms Clinical trial Immune system Internal medicine Biomarkers Tumor Tumor Microenvironment medicine Advanced disease Humans Pharmacology (medical) In patient Colorectal Neoplasms business Gastrointestinal Neoplasms |
| Zdroj: | Expert Review of Anticancer Therapy. 14:1219-1228 |
| ISSN: | 1744-8328 1473-7140 |
| DOI: | 10.1586/14737140.2014.947277 |
| Popis: | Immune-based strategies are the most promising treatments to improve cancer disease control. Early clinical trials are ongoing to test the safety and feasibility of immune-based therapies for gastrointestinal cancers. However, to date, immunotherapy has been only an experimental option for these diseases and a better understanding of their molecular, cellular, structural and clinical dissimilarities is crucial in the generation of tailored immunotherapeutic treatments. In this review, we will summarize the key mechanisms that regulate the action of immune system in cancer and the different immune-based approaches aimed at improving disease control in patients with advanced disease. We will then move on to discussing the current immunotherapeutic approaches in two types of gastrointestinal (colo-rectal and pancreatic) cancers, whose immune microenvironment has been lately object of intense analyses and has emerged as an important determinant of clinical outcome. |
| Databáze: | OpenAIRE |
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