Comparison of Lamina Cribrosa Curvature in Pseudoexfoliation and Primary Open-Angle Glaucoma
| Autor: | Youn Hye Jo, Min Kyung Song, Hun Jae Won, Joong Won Shin, Kyung Rim Sung |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Retinal Ganglion Cells medicine.medical_specialty Lamina genetic structures Open angle glaucoma Optic Disk Glaucoma Exfoliation Syndrome Logistic regression Tonometry Ocular Nerve Fibers Ophthalmology Optic Nerve Diseases medicine Humans Intraocular Pressure Aged Retrospective Studies Aged 80 and over Multivariable linear regression business.industry Pseudoexfoliation Odds ratio Middle Aged medicine.disease eye diseases Confidence interval Cross-Sectional Studies Female sense organs Visual Fields business Glaucoma Open-Angle Tomography Optical Coherence |
| Zdroj: | American Journal of Ophthalmology. 223:1-8 |
| ISSN: | 0002-9394 |
| Popis: | PURPOSE To compare lamina cribrosa curvature (LCC) in pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG) and to elucidate the factors associated with LCC in both groups. DESIGN Retrospective, cross-sectional study. METHOD Forty eyes with PXG and visual field mean deviation-matched 40 eyes with POAG were included. Spectral domain optical coherence tomography enhanced depth imaging was used to acquire LC images. The LCC index (LCCI) was calculated as LCC depth/LCC width × 100. Calculated LCCI values were compared between the PXG and POAG groups. Logistic regression analysis was performed to investigate the factors related to the presence of PXG. Factors associated with LCCI were determined by uni- and multivariable linear regression analyses in both groups. RESULT Visual field mean deviation (-11.7 ± 9.7 dB vs -1.0 ± 8.5 dB, P = .731) and retinal nerve fiber thickness (647.4 ± 22.7 μm vs 68.3 ± 19.9 μm, P = .857) did not differ between the 2 groups. However, the mean (8.8 ± 2.9 in PXG, 6.6 ± 1.9 in POAG) and sectoral LCCIs assessed at 0, 30, 60, 90, and 120° were significantly greater in the PXG than in the POAG group (all, P < .05), but not at 150° (P = .113). Logistic regression analysis revealed that higher average LCCI (odds ratio [OR] = 1.509 [95% confidence interval 1.180-2.047], P = .003) and older age (OR = 1.074 [95% confidence interval 1.017-1.147], P = .019) were associated with the presence of PXG. IOP was associated with mean LCCI only in the POAG group (β = 0.150 [95% confidence interval 0.018-0.281], P = .027) while none of the factors showed association with LCCI in PXG. CONCLUSION PXG eyes had more steeply curved LC than POAG eyes with a similar level of glaucoma severity. The clinical implication(s) of steeper LCC in PXG should be investigated in a forthcoming study. |
| Databáze: | OpenAIRE |
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