Origin, Frequency and Clinical Significance of Glandular Cells in Liquid-Based Pap Tests from Patients Posthysterectomy
| Autor: | Joan Cangiarella, Robert C. Wallach, Paul Elgert, Aylin Simsir, Risha B. Ramdall, Pascale Levine, Guoping Cai |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Pathology Histology medicine.medical_treatment Hysterectomy Pathology and Forensic Medicine Humans Medicine Clinical significance Aged Vaginal Smears Chemotherapy business.industry Keratin-7 Mucins Epithelial Cells Anatomical pathology General Medicine Uterine Cervical Dysplasia Glandular Cell medicine.anatomical_structure Liquid-based cytology Vagina Immunohistochemistry Liquid based Female business |
| Zdroj: | Acta Cytologica. 53:1-9 |
| ISSN: | 1938-2650 0001-5547 |
| DOI: | 10.1159/000325077 |
| Popis: | Objective To quantify the frequency and significance of glandular cells in posthysterectomy liquid-based (SurePath, TriPath Imaging, Burlington, North Carolina, U.S.A.) vaginal Pap tests. Study Design The presence of benign glandular cells in vaginal Pap tests from posthysterectomy patients represents a diagnostic challenge and may pose management issues. We investigated the presence, frequency and significance of glandular cells in 52 liquid-based (SurePath) vaginal Pap tests from posthysterectomy patients by combining cytomorphologic findings with adjunctive immunohistochemistry and mucin stains performed on cell block preparations and correlated the findings with clinical data. Results After performing these special studies, the frequency of reporting glandular cells in posthysterectomy Pap tests decreased from 3.5% to 1.2% of all vaginal Pap tests performed in a 6-month period. Conclusion A strong association of the presence of benign appearing glandular cells and a previous history of gynecological malignancy (71 %) and chemotherapy/radiation (59%) were noted, likely representing a regenerative process in response to injury or therapy. |
| Databáze: | OpenAIRE |
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