Pir-B inhibits the DC function and disturbs the Th17/Treg balance in lung cancer murine model
Autor: | Guonian Wang, Chunfeng Li, Linlin Dong, Kun Wang, Xiaoyu Zheng, Huaxing Wu, Mingyue Zhang |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Pir-B Cellular differentiation chemical and pharmacologic phenomena Inhibitory postsynaptic potential 03 medical and health sciences 0302 clinical medicine Immune system In vivo medicine Lung cancer Receptor Chemistry hemic and immune systems Transfection medicine.disease In vitro Treg lung cancer 030104 developmental biology Oncology 030220 oncology & carcinogenesis Immunology Cancer research Th17 immune Research Paper |
Zdroj: | Oncotarget |
ISSN: | 1949-2553 |
Popis: | Paired immunoglobulin-like receptor B (Pir-B) was an inhibitory receptor expressed on the surfaces of dendritic cells (DCs). Pir-B inhibit T helper (Th) 1 response and induce Th2 cell differentiation, leading to the imbalance of Th1/Th2 cells. However, the role and potential mechanism of Pir-B on the balance of Th17/regulatory T cells (Tregs) is still largely unknown in lung cancer murine model. In the present study, the DC function and Th17/Treg balance were destroyed during the progression of lung cancer and this was accompanied by an increased expression of Pir-B. After transfection with Pir-B siRNA or administration of IL-6 in vitro, the decreased response of Th17 cells were restored, whereas the augmented differentiation of Tregs was diminished. Further, the transfer of Pir-B silenced DCs or the injection of IL-6 in vivo increased Th17 response and decreased Treg differentiation. Our study has demonstrated that Pir-B inhibits the DC function and disturbs the Th17/Treg balance via IL-6 pathway during the progression of lung cancer, contributing to inhibited antitumor immunity. |
Databáze: | OpenAIRE |
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