Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture
| Autor: | Sajad H. Ahanger, Navneet Matharu |
|---|---|
| Přispěvatelé: | University of Zurich, Matharu, Navneet K |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
10018 Ophthalmology Clinic
Genetics 2716 Genetics (clinical) lcsh:QH426-470 DNA repair 610 Medicine & health architectural proteins Computational biology Review Biology Genome TAD boundaries Chromatin Chromosome conformation capture lcsh:Genetics 1311 Genetics chromatin architecture insulators Reprogramming Genetics (clinical) Genome architecture Genomic organization |
| Zdroj: | Genes Genes, Vol 6, Iss 3, Pp 790-811 (2015) |
| ISSN: | 2073-4425 |
| Popis: | The spatial organization of metazoan genomes has a direct influence on fundamental nuclear processes that include transcription, replication, and DNA repair. It is imperative to understand the mechanisms that shape the 3D organization of the eukaryotic genomes. Chromatin insulators have emerged as one of the central components of the genome organization tool-kit across species. Recent advancements in chromatin conformation capture technologies have provided important insights into the architectural role of insulators in genomic structuring. Insulators are involved in 3D genome organization at multiple spatial scales and are important for dynamic reorganization of chromatin structure during reprogramming and differentiation. In this review, we will discuss the classical view and our renewed understanding of insulators as global genome organizers. We will also discuss the plasticity of chromatin structure and its re-organization during pluripotency and differentiation and in situations of cellular stress. |
| Databáze: | OpenAIRE |
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