Possible indomethacin-aminoglycoside interaction in preterm infants
| Autor: | Yehoshua Zarfin, Gideon Koren, Stuart MacLeod, David Maresky, Max Perlman |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Digoxin
Combined use Indomethacin Renal function Infant Premature Diseases Pharmacology Electrolytes medicine Humans Drug Interactions Prospective Studies Amikacin Ductus Arteriosus Patent Kidney business.industry Aminoglycoside Infant Newborn Serum concentration Anti-Bacterial Agents Diuresis medicine.anatomical_structure Aminoglycosides Creatinine Pediatrics Perinatology and Child Health Toxicity Gentamicins business medicine.drug |
| Zdroj: | The Journal of pediatrics. 106(3) |
| ISSN: | 0022-3476 |
| Popis: | THE COMBINED USE OF AMINOGLYCOSIDES, which are eliminated almost entirely by the kidney, ~ and indomethacin, which tends to impair renal function, z may promote aminoglycoside accumulation and resulting toxicity 3-5 in preterm infants. We recently reported the interaction between indometh~tcin and digoxin in this age group resulting in significan t elevation of digoxin serum concentrations to potentially toxic levels. 6 In the present study, we prospectively assessed the effect of indomethacin on aminoglycoside serum Concentrations when both were given in clinically recommended doses. |
| Databáze: | OpenAIRE |
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