Polymorphisms in the human DNA polymerase beta gene
| Autor: | Yasushi Dobashi, Taro Shuin, Masahiro Yao, Soichiro Torigoe, Masahiko Hosaka, Yoshinobu Kubota |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
DNA polymerase DNA repair Molecular Sequence Data Gene mutation medicine.disease_cause Polymerase Chain Reaction law.invention chemistry.chemical_compound law Genetics medicine Tumor Cells Cultured Humans RNA Neoplasm Gene Genetics (clinical) Polymerase chain reaction Polymorphism Genetic biology Base Sequence Nucleic acid sequence Prostatic Neoplasms DNA Neoplasm DNA Polymerase I Molecular biology chemistry Mutation biology.protein Carcinogenesis Colorectal Neoplasms DNA |
| Zdroj: | Human genetics. 95(4) |
| ISSN: | 0340-6717 |
| Popis: | Recently, evidence has accumulated that mutations in DNA repair genes might be associated with certain steps in carcinogenesis. The DNA polymerase beta gene is one of the DNA repair genes, and mutations in it have been detected in 83% of human colorectal cancers. To assess the involvement of polymerase beta gene mutations in the development of human prostate cancers, we performed sequence analyses of human DNA samples. Unexpectedly, we found six regions that were polymorphic. This information should be taken into consideration at the time of sequence analysis of the DNA polymerase beta gene. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink