N-methyl-D-aspartate receptor subunit 1 regulates neurogenesis in the hippocampal dentate gyrus of schizophrenia-like mice
| Autor: | Yin-Ming Liu, Chun Zhang, Juan Ding, Quan-Rui Ma, Tao Sun, Juan Liu, Yi-Wei Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Intraperitoneal injection Hippocampus Hippocampal formation lcsh:RC346-429 hippocampal dentate gyrus 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience nerve regeneration schizophrenia MK-801 N-methyl-D-aspartate neurogenesis N-methyl-D-aspartate receptor N-methyl-Daspartate receptor subunit 1 BrdU Ki67 hippocampal neurogenesis neural regeneration Internal medicine medicine Receptor lcsh:Neurology. Diseases of the nervous system business.industry Dentate gyrus N-methyl-D-aspartate receptor subunit 1 Neurogenesis medicine.disease Pathophysiology 030104 developmental biology Endocrinology nervous system Schizophrenia sense organs business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Neural Regeneration Research, Vol 14, Iss 12, Pp 2112-2117 (2019) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | N-methyl-D-aspartate receptor hypofunction is the basis of pathophysiology in schizophrenia. Blocking the N-methyl-D-aspartate receptor impairs learning and memory abilities and induces pathological changes in the brain. Previous studies have paid little attention to the role of the N-methyl-D-aspartate receptor subunit 1 (NR1) in neurogenesis in the hippocampus of schizophrenia. A mouse model of schizophrenia was established by intraperitoneal injection of 0.6 mg/kg MK-801, once a day, for 14 days. In N-methyl-D-aspartate-treated mice, N-methyl-D-aspartate was administered by intracerebroventricular injection in schizophrenia mice on day 15. The number of NR1-, Ki67- or BrdU-immunoreactive cells in the dentate gyrus was measured by immunofluorescence staining. Our data showed the number of NR1-immunoreactive cells increased along with the decreasing numbers of BrdU- and Ki67-immunoreactive cells in the schizophrenia groups compared with the control group. N-methyl-D-aspartate could reverse the above changes. These results indicated that NR1 can regulate neurogenesis in the hippocampal dentate gyrus of schizophrenia mice, supporting NR1 as a promising therapeutic target in the treatment of schizophrenia. This study was approved by the Experimental Animal Ethics Committee of the Ningxia Medical University, China (approval No. 2014-014) on March 6, 2014. |
| Databáze: | OpenAIRE |
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