A clinicopathological study of triple-negative breast carcinoma in a patient cohort from a tertiary care center in Sri Lanka
Autor: | J. Fernando, H. D. Wijesinghe, Menaka D. S. Lokuhetty, G. K. Wijesinghe, Upul Senarath |
---|---|
Rok vydání: | 2020 |
Předmět: |
Adult
Microbiology (medical) Oncology medicine.medical_specialty prevalence lcsh:QR1-502 Triple Negative Breast Neoplasms lcsh:Microbiology Pathology and Forensic Medicine Cohort Studies Tertiary Care Centers Necrosis Basal (phylogenetics) Internal medicine lcsh:Pathology Biomarkers Tumor Humans Medicine breast carcinoma Stage (cooking) Aged Sri Lanka Aged 80 and over business.industry Proportional hazards model Age Factors triple negative breast carcinoma General Medicine Middle Aged Ductal carcinoma Prognosis Immunohistochemistry Receptors Estrogen Basal-Like Breast Carcinoma Cohort Female Triple-Negative Breast Carcinoma basal like breast carcinoma Receptors Progesterone business Breast carcinoma clinicopathological features lcsh:RB1-214 |
Zdroj: | Indian Journal of Pathology and Microbiology, Vol 63, Iss 3, Pp 388-396 (2020) |
ISSN: | 0377-4929 |
Popis: | Background: Triple negative breast carcinoma (TNBC) and basal-like breast carcinoma (BLBC) are subtypes of breast carcinoma (BCa) that are associated with poor survival. Aims: To study the prevalence, clinicopathological profile and survival of TNBC among a Sri Lankan patient cohort and to determine the proportion and predictive histological features of BLBC among TNBCs. Study Setting and Design: A cohort of 221 women undergoing primary surgery for BCa at a tertiary-care center in Sri Lanka was studied. Materials and Methods: Clinicopathological and follow-up information were collected by patient interviews and review of slides and clinical records. Estrogen, progesterone, HER2 receptors, and basal markers (CK5/6, CK14, EGFR, 34βE12) were evaluated immunohistochemically. Statistical Analysis: Data was analyzed with Chi-square test, multinomial logistic regression, and Cox regression using SPSS20.0. Results: Fifty-three (24%) tumors were triple-negative (95%CI = 18.37%–29.63%). On multivariate analysis, young age (P = 0.002), high Nottingham grade (P = 0.005), moderate to severe tumor necrosis (P = 0.004), absent ductal carcinoma in situ (DCIS) (P = 0.04), reduced vascular density at tumor edge (P = 0.016) and distinct cell margins (P = 0.047) predicted TNBC over luminal subgroups, whereas reduced vascular density (P = 0.004) and low TNM stage (P = 0.011) distinguished TNBC and HER2. BLBC accounted for 45.28% (95%CI 32.66%–58.55%-24/53) of TNBC. The presence of extensive necrosis in TNBC correlated significantly with BLBC (P = 0.03). The survival among the TNBC subgroup did not differ significantly from other subgroups. Conclusion: Twenty four percent were TNBCs by immunohistochemical analysis, comparable to studies in the Indian subcontinent, however higher than the West. TNBC status correlated with younger age, high tumor grade, necrosis, absent DCIS, reduced vascular density at tumor edge, and distinct cell margins. The presence of moderate to extensive necrosis in TNBC was predictive of BLBC. |
Databáze: | OpenAIRE |
Externí odkaz: |