Establishment and Maintenance of Cell Polarity During Leukocyte Chemotaxis
| Autor: | Santos Mañes, Concepción Gómez-Moutón |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Polarity (physics)
Cell Membrane Cell Polarity Cell migration Review Cell Biology Biology Cell biology Cell membrane Chemotaxis Leukocyte Phosphatidylinositol 3-Kinases Cellular and Molecular Neuroscience medicine.anatomical_structure Cell polarity Leukocytes medicine Asymmetric cell division Animals Humans Actin Leukocyte chemotaxis Signal Transduction Epithelial polarity |
| Zdroj: | Cell Adhesion & Migration. 1:69-76 |
| ISSN: | 1933-6926 1933-6918 |
| Popis: | The term polarity refers to the differential distribution of the macromolecular elements of a cell, resulting in its asymmetry in function, shape and/or content. Polarity is a fundamental property of all metazoan cells in at least some stages, and is pivotal to processes such as epithelial differentiation (apical/basal polarity), coordinated cell activity within the plane of a tissue (planar cell polarity), asymmetric cell division, and cell migration. In the last case, an apparently symmetric cell responds to directional cues provided by chemoattractants, creating a polarity axis that runs from the cell anterior, or leading edge, in which actin polymerization takes place, to the cell posterior (termed uropod in leukocytes), in which acto-myosin contraction occurs. Here we will review some of the molecular mechanisms through which chemoattractants break cell symmetry to trigger directed migration, focusing on cells of the immune system. We briefly highlight some common or apparently contradictory pathways reported as important for polarity in other cells, as this suggests conserved or cell type-specific mechanisms in eukaryotic cell chemotaxis. |
| Databáze: | OpenAIRE |
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