Dental pulp stem cells response on the nanotopography of scaffold to regenerate dentin-pulp complex tissue

Autor: Yulita Kristanti, Retno Ardhani, Pribadi Santosa, Rasda Diana
Rok vydání: 2020
Předmět:
0301 basic medicine
Scaffold
IGF
insulin-like growth factor
PLGA
poly-dl-lactic-co-glycolic acid
Nanotopography
Review
FGF2
fibroblast growth factor-2
Dental pulp stem cell
PHMS
polyhydroxymethylsiloxane
PDGF
platelet-derived growth factor
Dentin-pulp complex tissue
0302 clinical medicine
Regenerative dentistry
Tissue engineering
PGA
polyglycolic acid
PLLA
poly-l-lactic acid
lcsh:R5-920
lcsh:Cytology
Chemistry
GDNF
glial cell line-derived neurotrophic factor
Biomaterial
GelMA
methacrylated gelatin
RGO
reduced graphene oxide
Cell migration
TNF-α
t umour necrosis factor-alpha
VEGF
vascular endothelial growth factor
ECM
extracellular matrix
Cell biology
BDNF
brain-derived neurotrophic factor
LPS
lipopolysaccharide
Stem cell
lcsh:Medicine (General)
SHED
stem cells from human exfoliated deciduous teeth
SACP
stem cells from apical papilla
SDF-1
stromal cell-derived factor-1
NGF
nerve growth factor
Biomedical Engineering
Biomaterials
03 medical and health sciences
stomatognathic system
TGF-β
transforming growth factor-β
Dental pulp stem cells
ION-CPC
iron oxide nanoparticle-incorporating calcium phosphate cement
lcsh:QH573-671
GO
graphene oxide
BMP
bone morphogenetic protein
PCL
polycaprolactone
stomatognathic diseases
DPSC
dental pulp stem cell
030104 developmental biology
PEGMA
poly(ethylene glycol) dimethacrylate
Pulp (tooth)
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Regenerative Therapy, Vol 15, Iss, Pp 243-250 (2020)
Regenerative Therapy
ISSN: 2352-3204
DOI: 10.1016/j.reth.2020.09.007
Popis: The study of regenerative dentistry receives a fast growing interest. The potential ability of the dentin-pulp complex to regenerate is both promising and perplexing. To answer the challenging nature of the dental environment, scientists have developed various combinations of biomaterial scaffolds, stem cells, and incorporation of several growth factors. One of the crucial elements of this tissue engineering plan is the selection and fabrication of scaffolds. However, further findings suggest that cell behavior hugely depends on mechanical signaling. Nanotopography modifies scaffolds to alter cell migration and differentiation. However, to the best of the author's knowledge, there are very few studies addressing the correlation between nanotopography and dentin-pulp complex regeneration. Therefore, this article presents a comprehensive review of these studies and suggests a direction for future developments, particularly in the incorporation of nanotopography design for dentin-pulp complex regeneration.
Highlights • Nanotopographical size and forms affects different dental pulp stem cell's response. • Dental pulp stem cell responses both molecular and mechanical cues from the environment. • The nanotophography of scaffold generates mechanotransduction on dental pulp stem cell. • Mechanotransduction is related to gene expression, arrangement, and morphological changes of dental pulp stem cell. • Smaller size nanotopography tends to enhance cell attachment; the larger one increases differentiation and proliferation.
Databáze: OpenAIRE
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