Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans
| Autor: | John J. Mackrill, Barbara Doyle Prestwich, Florence O. McCarthy, Roberta A. Kehoe, Elaine C. O’Sullivan, Mary L. McKee, Limian Zheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Phytophthora infestans ellipticinium salts lcsh:Medicine Growth inhibitory zoosporogenesis 01 natural sciences Ellipticine Ellipticines 03 medical and health sciences chemistry.chemical_compound Derivative (finance) isoellipticines oomycete Immunology and Allergy Molecular Biology 030304 developmental biology 0303 health sciences Natural product General Immunology and Microbiology biology 010405 organic chemistry business.industry lcsh:R biology.organism_classification 0104 chemical sciences Biotechnology Fungicide Infectious Diseases chemistry mycelial growth business |
| Zdroj: | Pathogens, Vol 9, Iss 558, p 558 (2020) Pathogens Volume 9 Issue 7 |
| ISSN: | 2076-0817 |
| Popis: | The pathogen Phytophthora infestans is responsible for worldwide catastrophic crop damage and discovery of new inhibitors of this organism is of paramount agricultural and industrial importance. Current strategies for crop treatment are inadequate with limitations of efficacy and market alternatives. Ellipticines have recently been reported to have fungicidal properties and have been assessed against P. infestans growth with promising results. We hereby report a probe of the ellipticine framework to investigate the alkyl subunit and screen a set ellipticines and derivatives to identify new lead compounds to act against P. infestans. A series of ellipticinium salt derivatives have been identified with exceptional growth inhibitory activity and apparent lack of toxicity towards a human cell-line surpassing the effect of known and marketed fungicides. This report identifies the potential of this natural product derivative as a novel fungicide. |
| Databáze: | OpenAIRE |
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