Association of IGF-1 CA(n) and IGFBP3 rs2854746 Polymorphisms with Endometrial Polyp Risk
| Autor: | Milton Wajman, Marcos Tcherniakovsky, Thomas Moscovitz, Luciano de Melo Pompei, Sergio Haimovich, Angela Van Nimwegen, Pedro Leopoldo Silva Doria, César Eduardo Fernandes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Endometri--Malalties--Diagnòstic Adult medicine.medical_specialty Genotype Article Subject medicine.medical_treatment IGFBP3 lcsh:Medicine Biology Endometrium General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Polyps Risk Factors Internal medicine medicine Endometrial Polyp Humans Pòlips (Patologia) Genotip Insulin-Like Growth Factor I Genotyping Polymorphism Genetic General Immunology and Microbiology Growth factor lcsh:R Case-control study General Medicine Odds ratio Middle Aged 030104 developmental biology Endocrinology medicine.anatomical_structure Insulin-Like Growth Factor Binding Protein 3 030220 oncology & carcinogenesis Case-Control Studies Female Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2018 (2018) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2018/8704346 |
| Popis: | Introduction. Insulin-like growth factor 1 (IGF-1) is a peptide growth factor that promotes cell proliferation and inhibits apoptosis. The bioavailability of IGF-1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3). Genetic variations influence the levels of IGF-1 and IGFBP3. The purpose of this study was to examine the association of polymorphisms IGF-1 CA(n) and IGFBP3 rs2854746 with risk of endometrial polyps. Materials and Methods. Case control observational study, composed of 104 women with antecedent of endometrial polyp (case group) and 81 postmenopausal women without antecedent of endometrial diseases (control group). Genotyping of IGF-1 CA(n) was performed by PCR and fragment analysis by capillary electrophoresis, and genotyping of IGFBP3 rs2854746 was performed by PCR-HRM. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression. Results. The genotype IGF-1 CA(19)/CA(19) was associated with an increased endometrial polyp risk (OR=2,57; IC 95%= 1,09 - 6,01); this was also found when combining it with CA(>19)/CA(n) genotypes (OR=2,18; IC 95%= 1,06-4,47). The IGFBP3 rs2854746 analyses showed the CG genotype having a protective effect for endometrial polyp (OR=0,37; IC 95%= 0,19-0,73), fact also observed when grouping CG and GG carriers (OR=0,51; IC 95%= 0,28-0,93). Conclusion. The genotypes CA(19)/CA(19) and CA(19)/CA(19) + CA(>19)/CA(n) of the IGF-1 CA(n) may be considered a risk for endometrial polyp, whereas the genotypes CG and CG + GG of IGFBP3 rs2854746 polymorphism have an inverse effect of endometrial polyp risk. |
| Databáze: | OpenAIRE |
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