Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis

Autor:	Ker Y. Cheah, Juliana E Bajic, Kerry A. Lymn, Suzanne Mashtoub, Lorrinne S Lampton, Gordon S. Howarth, Georgina L Eden
Rok vydání:	2016
Předmět:	Mucositis Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty Pathology Medicine (miscellaneous) Ileum Protective Agents Dasyproctidae Gastroenterology Jejunum Random Allocation 03 medical and health sciences 0302 clinical medicine Gastrointestinal Agents Intestinal mucosa hemic and lymphatic diseases Internal medicine Animals Medicine Intestinal Mucosa Olive Oil Gastrointestinal agent Nutrition and Dietetics biology business.industry Anti-Inflammatory Agents Non-Steroidal Organ Size medicine.disease Lipids Enteritis Small intestine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Emu oil Myeloperoxidase Dietary Supplements biology.protein Female 030211 gastroenterology & hepatology Fluorouracil business Oils Biomarkers
Zdroj:	Nutrition and Cancer. 68:1171-1180
ISSN:	1532-7914 0163-5581
Popis:	Chemotherapy-induced mucositis is characterized by inflammation and ulcerating lesions lining the alimentary tract. Emu Oil and Lyprinol™ have independently demonstrated their therapeutic potential in intestinal inflammatory disorders, including mucositis. We investigated Emu Oil and Lyprinol™ in combination for their further potential to alleviate chemotherapy-induced mucositis in rats. Rats were gavaged with (1 ml) water, Olive Oil, Emu Oil + Olive Oil, Lyprinol™ + Olive Oil or Emu Oil + Lyprinol™ from Days 0 to 7, injected with saline (control) or 5-Fluorouracil (5-FU) on Day 5 and euthanized on Day 8. Myeloperoxidase (MPO) activity (indicative of acute inflammation), histological severity scores, and intestinal architecture were quantified. Myeloperoxidase activity was significantly increased in the jejunum and ileum following 5-FU, compared to saline controls. Both Olive Oil and Emu Oil + Lyprinol™ significantly reduced jejunal MPO levels (1.8-fold and 1.7-fold, respectively), whereas only Emu Oil + Lyprinol™ significantly decreased ileal MPO levels, relative to 5-FU controls. All oil treatments decreased histological severity scores in the jejunum and ileum, and normalized crypt depth in the mid small intestine, relative to 5-FU controls. Emu Oil combined with Lyprinol™ partially reduced acute small intestinal inflammation. Isolating bioactive constituents of these naturally sourced oils could provide a more targeted strategy to protect against intestinal mucositis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408af495743c31ff962d14bd01259ed3 https://doi.org/10.1080/01635581.2016.1208829 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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