Transmissão recente de Mycobacterium tuberculosis resistentes aos antimicrobianos em população carcerária no sul do Brasil
| Autor: | Lia Gonçalves Possuelo, Ana Júlia Reis, Luciana de Souza Nunes, Andréia Rosane de Moura Valim, Simone Maria Martini de David |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Tuberculosis Genotype Epidemiologia molecular 030231 tropical medicine 030106 microbiology Drug resistance Brief Communication Smear microscopy Mycobacterium tuberculosis Young Adult 03 medical and health sciences Diseases of the respiratory system 0302 clinical medicine Tuberculosis Multidrug-Resistant medicine Cluster Analysis Humans Tuberculose Molecular Biology Retrospective Studies Gynecology lcsh:RC705-779 Prison population Prisões biology Molecular epidemiology RC705-779 business.industry Recent transmission Sputum lcsh:Diseases of the respiratory system Middle Aged biology.organism_classification Active tuberculosis medicine.disease Cross-Sectional Studies Prisons Educational Status business Brazil |
| Zdroj: | Jornal Brasileiro de Pneumologia, Vol 42, Iss 4, Pp 286-289 (2016) Jornal Brasileiro de Pneumologia, Vol 42, Iss 4, Pp 286-289 Jornal Brasileiro de Pneumologia, Volume: 42, Issue: 4, Pages: 286-289, Published: AUG 2016 Jornal Brasileiro de Pneumologia |
| ISSN: | 1806-3756 |
| Popis: | We conducted a cross-sectional, retrospective study, characterized by classical and molecular epidemiology, involving M. tuberculosis isolates from a regional prison in southern Brazil. Between January of 2011 and August of 2014, 379 prisoners underwent sputum smear microscopy and culture; 53 (13.9%) were diagnosed with active tuberculosis. Of those, 8 (22.9%) presented with isoniazid-resistant tuberculosis. Strain genotyping was carried out by 15-locus mycobacterial interspersed repetitive unit-variable-number tandem-repeat analysis; 68.6% of the patients were distributed into five clusters, and 87.5% of the resistant cases were in the same cluster. The frequency of drug-resistant tuberculosis cases and the rate of recent transmission were high. Our data suggest the need to implement an effective tuberculosis control program within the prison system. RESUMO Estudo transversal, retrospectivo, com isolados de M. tuberculosis de pacientes de um presídio regional no sul do Brasil, caracterizado através de epidemiologia clássica e molecular. Entre janeiro de 2011 e agosto de 2014, 379 detentos foram submetidos a baciloscopia e cultura, sendo 53 (13,9%) diagnosticados com tuberculose ativa. Desses, 8 (22,9%) apresentavam tuberculose resistente a isoniazida. A genotipagem das cepas foi realizada por 15-locus mycobacterial interspersed repetitive units-variable number of tandem repeat analysis; 68,6% dos pacientes estavam distribuídos em cinco clusters, e 87,5% dos casos resistentes estavam em um mesmo cluster. Verificou-se uma frequência elevada de casos de resistência e alta taxa de transmissão recente. Estes dados sugerem a necessidade da implantação de um programa efetivo de controle da tuberculose no sistema prisional. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|