GDF11 Treatment Attenuates the Recovery of Skeletal Muscle Function After Injury in Older Rats
| Autor: | Julius Kahn, Ashraf Khalil, Jennifer Ahlberg, Yu Zhou, David Dukes, Maria Myzithras, Michael Franti, Priyanka Gupta, Tracy Criswell, David B. Hayes, Neel Sharma |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty Population Pharmaceutical Science Biology 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Internal medicine medicine Animals Humans Regeneration In patient Muscle Skeletal education education.field_of_study Regeneration (biology) Skeletal muscle medicine.disease Functional recovery Fibrosis Rats Growth Differentiation Factors Disease Models Animal 030104 developmental biology Endocrinology medicine.anatomical_structure Rats Inbred Lew Sarcopenia Bone Morphogenetic Proteins GDF11 Quality of Life 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | The AAPS Journal. 19:431-437 |
| ISSN: | 1550-7416 |
| DOI: | 10.1208/s12248-016-0024-x |
| Popis: | Loss of skeletal muscle mass and function results in loss of mobility for elderly patients. Novel therapies that can protect and/or restore muscle function during aging would have profound effects on the quality of life for this population. Growth differentiation factor 11 (GDF11) has been proposed as a "youthful" circulating factor that can restore cardiac, neural, and skeletal muscle functions in aging animals. However, conflicting data has been recently published that casts doubt on these assertions. We used a complex rat model of skeletal muscle injury that physiologically mimics injuries seen in patients; to investigate the ability of GDF11 and to enhance skeletal muscle regeneration after injury in older rats. Our data showed that GDF11 treatment resulted in a significant increase in tissue fibrosis, accompanied by attenuated functional recovery, as compared to animals treated with vehicle alone. GDF11 impaired the recovery of skeletal muscle function in older rats after injury. |
| Databáze: | OpenAIRE |
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