Could Hop-derived Bitter Compounds Improve Glucose Homeostasis by Stimulating the Secretion of GLP-1?
| Autor: | Giovanna Muscogiuri, Luigi Barrea, Gian Carlo Tenore, Giuseppe Annunziata, Angela Arnone, Annamaria Colao, Silvia Savastano |
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| Přispěvatelé: | Barrea, Luigi, Annunziata, Giuseppe, Muscogiuri, Giovanna, Arnone, Angela, Tenore, GIAN CARLO, Colao, Annamaria, Savastano, Silvia |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Humulus lupulus 030309 nutrition & dietetics Enteroendocrine Cells Hop-derived Bitter Compounds Industrial and Manufacturing Engineering Glucose Homeostasi Receptors G-Protein-Coupled 03 medical and health sciences 0404 agricultural biotechnology Taste receptor Glucagon-Like Peptide 1 Internal medicine medicine Glucose homeostasis Animals Homeostasis Humans Secretion Receptor Humulus 0303 health sciences biology Plant Extracts food and beverages Beer 04 agricultural and veterinary sciences General Medicine Sweetness biology.organism_classification Taste Buds 040401 food science Gastrointestinal Tract Endocrinology Glucose Taste GLP-1 Food Science Hormone |
| Popis: | Hops (Humulus lupulus L.) is by far the greatest contributors to the bitter property of beer. Over the past years, a large body of evidence demonstrated the presence of taste receptors in different locations of the oral cavity. In addition to the taste buds of the tongue, cells expressing these receptors have been identified in olfactory bulbs, respiratory and gastrointestinal tract. In the gut, the attention was mainly directed to sweet Taste Receptor (T1R) and bitter Taste Receptor (T2R) receptors. In particular, T2R has shown to modulate secretion of different gut hormones, mainly Glucagon-like Peptide 1 (GLP-1), which are involved in the regulation of glucose homeostasis and the control of gut motility, thereby increasing the sense of satiety. Scientific interest in the activity of bitter taste receptors emerges because of their wide distribution in the human species and the large range of natural substances that interact with them. Beer, whose alcohol content is lower than in other common alcoholic beverages, contains a considerable amount of bitter compounds and current scientific evidence shows a direct effect of beer compounds on glucose homeostasis. The purpose of this paper is to review the available literature data in order to substantiate the novel hypothesis of a possible direct effect of hop-derived bitter compounds on secretion of GLP-1, through the activation of T2R, with consequent improvement of glucose homeostasis. |
| Databáze: | OpenAIRE |
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