NSUN5 promotes progression and predicts poor prognosis in hepatocellular carcinoma

Autor:	Xiao-Wen, Zhang, Lu-Yi, Wu, Hui-Rong, Liu, Yan, Huang, Qin, Qi, Rui, Zhong, Lu, Zhu, Chun-Fang, Gao, Lin, Zhou, Jian, Yu, Huan-Gan, Wu
Rok vydání:	2022
Předmět:	Cancer Research Oncology
Zdroj:	Oncology Letters. 24
ISSN:	1792-1082 1792-1074
DOI:	10.3892/ol.2022.13559
Popis:	The 5-methylcytosine (m5C) RNA methyltransferase NOP2/Sun RNA methyltransferase 5 (NSUN5) has been reported to serve important roles in numerous diseases. However, the functions and clinical significance of NSUN5 in hepatocellular carcinoma (HCC) remain unknown. Clinical information and NSUN5 mRNA sequencing data for 374 patients with HCC were downloaded from The Cancer Genome Atlas (TCGA) database, and NSUN5 mRNA and protein expression levels in 120 patients with HCC (present study cohorts) were assessed using reverse transcription-quantitative PCR, western blotting or immunohistochemistry. The association between NSUN5 mRNA and protein expression levels and the clinical characteristics (or prognosis) of patients with HCC was analyzed using the χ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40866d0f518ad46f66678d2a07aa4d83 https://doi.org/10.3892/ol.2022.13559 Zobrazit plný text záznamu