Influence of magnesium supplementation and L-type calcium channel blocker on haloperidol-induced movement disturbances
| Autor: | Raquel Cristine Silva Barcelos, Marilise Escobar Burger, Laura Hautrive Milanesi, Vinicia Garzela Metz, Maikel Kronbauer, Domenika Rubert Rossato, Karine Roversi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Calcium Channels L-Type Nifedipine medicine.drug_class Movement Striatum Calcium channel blocker Receptors N-Methyl-D-Aspartate 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Dopamine receptor D2 Internal medicine medicine Haloperidol Animals L-type calcium channel Magnesium Rats Wistar 030304 developmental biology 0303 health sciences Dyskinesias Movement Disorders Voltage-dependent calcium channel Chemistry Brain biochemical phenomena metabolism and nutrition Calcium Channel Blockers Corpus Striatum Rats Neostriatum Substantia Nigra Endocrinology nervous system NMDA receptor 030217 neurology & neurosurgery medicine.drug Antipsychotic Agents |
| Zdroj: | Behavioural brain research. 374 |
| ISSN: | 1872-7549 |
| Popis: | Haloperidol (Hal) is an antipsychotic related to movement disorders. Magnesium (Mg) showed benefits on orofacial dyskinesia (OD), suggesting its involvement with N-methyl-D-aspartate receptors (NMDAR) since it acts blocking calcium channels. Comparisons between nifedipine (NIF; a calcium channel blocker) and Mg were performed to establish the Mg mechanism. Male rats concomitantly received Hal and Mg or NIF for 28 days, and OD behaviors were weekly assessed. Both Mg and NIF decreased Hal-induced OD. Hal increased Ca2+-ATPase activity in the striatum, and Mg reversed it. In the cortex, both Mg and NIF decreased such activity. Dopaminergic and glutamatergic immunoreactivity were modified by Hal and treatments: i) in the cortex: Hal reduced D1R and D2R, increasing NMDAR immunoreactivity. Mg and NIF reversed this Hal influence on D1R and NMDAR, while only Mg reversed Hal effects on D2R levels; ii) in the striatum: Hal decreased D2R and increased NMDAR while Mg and NIF decreased D1R and reversed the Hal-induced decreasing D2R levels. Only Mg reversed the Hal-induced increasing NMDAR levels; iii) in the substantia nigra (SN): while Hal increased D1R, D2R, and NMDAR, both Mg and NIF reversed this influence on D2R, but only Mg reversed the Hal-influence on D1R levels. Only NIF reversed the Hal effects on NMDAR immunoreactivity. These findings allow us to propose that Mg may be useful to minimize Hal-induced movement disturbances. Mg molecular mechanism seems to be involved with a calcium channel blocker because the NIF group showed less expressive effects than the Mg group. |
| Databáze: | OpenAIRE |
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