Anti-diabetic Role of Adropin in Streptozotocin Induced Diabetic Rats via Alteration of PI3K/Akt and Insulin Signaling Pathway
| Autor: | Zhiqiang Kang, Feng-Li Li, Yu Mao, Haoyun Li, Lei Li, Jing Li, Ling-Yu Xu, Hong-Mei Liu, Li He, Fang Luo, Huan-Huan Wang, Li-Ge Song, Ya-Jie Huo, Fengjiao Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty General Chemical Engineering medicine.medical_treatment AMP-Activated Protein Kinases Streptozocin Diabetes Mellitus Experimental Phosphatidylinositol 3-Kinases chemistry.chemical_compound Diabetes mellitus Internal medicine medicine Animals Hypoglycemic Agents Insulin Rats Wistar Protein kinase B Dose-Response Relationship Drug biology AMPK Blood Proteins General Medicine General Chemistry Lipid Metabolism medicine.disease Streptozotocin Insulin receptor Endocrinology chemistry Low-density lipoprotein biology.protein Peptides Proto-Oncogene Proteins c-akt GLUT4 Signal Transduction medicine.drug |
| Zdroj: | Journal of Oleo Science. 70:657-664 |
| ISSN: | 1347-3352 1345-8957 |
| Popis: | Diabetes mellitus (DM) is a hyperglycemia-related multifactorial condition with an elevated risk of microvascular and microvascular complications associated with this disease. The current experimental study was to examine the antidiabetic activity of streptozotocin (STZ)-induced adropin against diabetic rats by altering the PI3K/Akt and insulin signaling pathways. STZ (60 mg/kg) was used for the induction of DM and rats were divided into different groups and received the adropin (20, 40 and 80 mg/kg) and glibenclamide (10 mg/kg) till 28 days. Body weight, plasma insulin, blood glucose and food intake were estimated, respectively. Biochemical enzymes, carbohydrate enzymes, lipid parameters, AMPK and insulin signalling pathway parameters were estimated. GLUT4 and PPARγ expression were also estimated. Oral administration of adropin significantly (p < 0.001) increased the glycogen, glucose-6-phosphatase dehydrogenase, insulin, hexokinase and belittled the blood glucose level, fructose 1-6-biphosphatase, glucose-6-phosphatase at dose dependent manner. Adropin significantly (p < 0.001) reduced the level of triglyceride, cholesterol, low density lipoprotein, very low density lipoprotein and increased the level of high density lipoprotein at dose dependent manner. Adropin significantly (p < 0.001) activated the Akt, IRS-2, IRS-1, IR, p-AKT and PI3k, which are the key modulator molecules of PI3K/Akt, AMPK and insulin signalling pathway in DM rats. The current experimental study confirms the anti-diabetic effect of adropin on DM rats induced by AMPK and insulin signalling pathway against STZ. |
| Databáze: | OpenAIRE |
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