Area specific alterations in muscarinic stimulated low Km GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction
| Autor: | J. A. Joseph, Richelle Cutler, Rafael Villalobos-Molina, Keiji Yamagami, George S. Roth |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Aging Central nervous system Hippocampus GTPase Biology GTP Phosphohydrolases Alzheimer Disease Internal medicine Basal ganglia Muscarinic acetylcholine receptor medicine Humans Molecular Biology Aged Aged 80 and over General Neuroscience Frontal gyrus medicine.disease Receptors Muscarinic Stimulation Chemical Enzyme Activation Kinetics Endocrinology medicine.anatomical_structure Superior frontal gyrus Carbachol Neurology (clinical) Alzheimer's disease Developmental Biology Signal Transduction |
| Zdroj: | Brain research. 664(1-2) |
| ISSN: | 0006-8993 |
| Popis: | Carbachol-stimulated low Km GTPase activity (an index of muscarinic receptor-G protein coupling) was examined in hippocampus, basal ganglia, orbital frontal gyrus and superior frontal gyrus obtained from mature, aged and Alzheimer's Disease (AD) groups. Results indicated that carbachol-stimulated low Km GTPase activities in basal ganglia were as follows: mature controls > aged > AD, and there was a trend toward a similar pattern of decline in the hippocampus. No differences were seen in the two cortical areas examined; however, carbachol-stimulated low Km GTPase activity was small in the mature controls. Importantly, there were significant negative correlations between disease duration and carbachol-stimulated low Km GTPase activity in all areas examined except the orbital frontal gyrus. The longer the duration of the disease the lower the carbachol-stimulated low Km GTPase activity. Results suggest that age and disease-related changes in mAChR-G protein interactions in the basal ganglia may contribute to reduced signal transduction (ST). In addition, since decreased carbachol-stimulated low Km GTPase activity has also been observed in the aged rat; thus, investigations of the factors involved in decrements in signal transduction in the aged rat may be useful for understanding these alterations in aged humans or victims of AD. |
| Databáze: | OpenAIRE |
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