Immunohistochemical localization of notch signaling molecules in ameloblastomas
| Autor: | Hiromasa Hasegawa, Toshiyuki Kawakami, Keisuke Nakano, Mitsuhiro Takayama, Katsutoshi Kubo, Hatsuhiko Maeda, Waka Yoshida, E. Muraki, Masato Jinno |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cellular differentiation Notch signaling pathway Morphogenesis lcsh:Medicine Biology Notch Jagged Ameloblastoma Young Adult Serrate-Jagged Proteins mental disorders medicine Cell differentiation Humans Receptor Notch1 Notch signaling Cuboidal Cell Research Calcium-Binding Proteins lcsh:R Membrane Proteins General Medicine medicine.disease Jaw Neoplasms Immunohistochemistry Jagged-1 Protein Intercellular Signaling Peptides and Proteins Female Signal Transduction |
| Zdroj: | European Journal of Medical Research, Vol 16, Iss 6, p 253 (2011) European Journal of Medical Research |
| Popis: | We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive staining were also frequently observed, while only occasionally positive in peripheral cells, especially in cuboidal cells. The results showed that these morphogenesis regulation factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratios were frequently positive, and the ratios were nearly the same between the varied histopathological, cytological patterns. However, the less-differentiated cells were fewer in number than that of well-differentiated cells. |
| Databáze: | OpenAIRE |
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