Value of the cell cycle arrest biomarkers in the diagnosis of pregnancy-related acute kidney injury
| Autor: | Hesham Kamal Habeeb Keryakos, Fatma Mohamed Mohamed Kamel, Mahmoud H Khedr, Osama El Minshawy, Ayman Moheb Youssuf, Mostafa A. Abu Elela |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty IGFBP7 Urinary system 030232 urology & nephrology Biophysics Tissue inhibitor of metalloproteinases-2 (TIMP-2) Protein Serine-Threonine Kinases Sensitivity and Specificity Biochemistry Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Insulin-like growth factor-binding protein 7 (IGFBP7) Internal medicine medicine Humans Pregnancy related acute kidney injury Molecular Biology Diagnostics & Biomarkers Research Articles Tissue Inhibitor of Metalloproteinase-2 Eclampsia business.industry Incidence (epidemiology) Intracellular Signaling Peptides and Proteins Acute kidney injury 030208 emergency & critical care medicine Cell Cycle Checkpoints Cell Biology Acute Kidney Injury Middle Aged medicine.disease Insulin-Like Growth Factor Binding Proteins Pregnancy Complications Cell Cycle Growth & Proliferation Biomarker (medicine) Female Translational Science Cell-cycle arrest biomarkers business Biomarkers Postpartum period |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| DOI: | 10.1042/bsr20200962 |
| Popis: | Background: Pregnancy-related acute kidney injury (PRAKI) is still a common serious problem in developing countries. Insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor metalloproteinases-2 (TIMP-2) can identify critically ill patients at risk for the development of severe AKI. Aim: To identify main causes and timing of PRAKI and to study the G1 cell cycle arrest biomarkers in cases diagnosed with (PRAKI) as a diagnostic tool. Methods: 80 pregnant women diagnosed with PRAKI were recruited from a single hospital as well as 30 age-matched pregnant women with normal pregnancy participated in the present study. A urine specimen was collected from all study participants with established AKI within 24 h of ICU admission to measure [TIMP-2]*[IGFBP7]. Results: The incidence of PRAKI was 1.1%. The most common cause of PRAKI is pre-eclampsia/eclampsia spectrum (61%). Most of the cases occur in the third trimester (60%) and postpartum period (23%). At a cutoff 0.33 ng/ml, the estimated sensitivity and specificity of urinary [TIMP-2]*[IGFBP7] in predicting PRAKI is 100% (95% CI) with NPV and PPV are 100%. Conclusion: Urinary [TIMP-2]*[IGFBP7] serves as a sensitive and specific biomarker in the diagnosis of PRAKI. |
| Databáze: | OpenAIRE |
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