Effects of bradykinin receptor agonists, and captopril and thiorphan in ferret isolated trachea: evidence for bradykinin generation in vitro
| Autor: | Mark A. DeSiato, Stephen G. Farmer, Terasa Broom |
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| Rok vydání: | 1994 |
| Předmět: |
Agonist
Male medicine.medical_specialty Thiorphan Captopril medicine.drug_class Bradykinin Biology In Vitro Techniques chemistry.chemical_compound Internal medicine medicine Animals Bradykinin receptor Receptor Bradykinin Receptor Antagonists Pharmacology Receptors Bradykinin Ferrets respiratory system Receptor antagonist Trachea Endocrinology chemistry medicine.symptom Muscle contraction medicine.drug Muscle Contraction |
| Zdroj: | European journal of pharmacology. 259(3) |
| ISSN: | 0014-2999 |
| Popis: | Bradykinin B2 receptor agonists, but not a B1 receptor agonist, were potent spasmogens of ferret isolated trachea. Bradykinin-induced contractions were unaffected by several pharmacological agents, indicating a direct effect on airway smooth muscle B2 receptors. Captopril plus thiorphan caused contractions in approximately 70% of preparations that were abolished by B2 receptor antagonists, but not by B1 receptor antagonist. Thus, ferret tracheal tissues appear capable of releasing and degrading kinins in vitro. Inhibition of peptide degradation with captopril and thiorphan may allow the endogenous kinins to accumulate in concentrations sufficient to elicit tracheal contraction via activation of B2 receptors. |
| Databáze: | OpenAIRE |
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