Inhibition of human immunodeficiency virus type 1 reverse transcriptase, protease and integrase by bovine milk proteins
| Autor: | X.Y. Ye, T.B. Ng, T.K. Au, C.C. Wan, T.L. Lam |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Bovine milk
medicine.medical_treatment HIV Infections HIV Integrase Virus Replication General Biochemistry Genetics and Molecular Biology HIV Protease Casein medicine Animals Humans General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification Protease biology Lactoferrin Lactoperoxidase virus diseases General Medicine Milk Proteins Virology Molecular biology HIV Reverse Transcriptase Reverse transcriptase Integrase Enzyme chemistry HIV-1 biology.protein Cattle Female |
| Zdroj: | Life Sciences. 69:2217-2223 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(01)01311-x |
| Popis: | Different proteins have been isolated from bovine milk including lactoferrin, lactoperoxidase, glycolactin, angiogenin-1, lactogenin, alpha-lactalbumin, lactoglobulin and casein. These proteins have been assayed for inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, protease and integrase, enzymes crucial to the HIV-1 life cycle. It was found that different milk proteins inhibited the three aforementioned HIV enzymes to different extents. Lactoferrin strongly inhibited HIV-1 reverse transcriptase but only slightly inhibited HIV-1 protease and integrase. On the other hand, alpha-lactalbumin, beta-lactoglobulin and casein inhibited HIV-1 protease and integrase to an appreciable extent but did not inhibit HIV-1 reverse transcriptase. Glycolactin and angiogenin-1 suppressed the activity of HIV-1 reverse transcriptase by a moderate extent but more powerfully inhibited HIV-1 protease and integrase. In comparison with the other milk proteins glycolactin was a strong inhibitor of HIV-1 protease and integrase and a moderate inhibitor of HIV-1 reverse transcriptase. Lactogenin was a strong inhibitor of HIV-1 integrase, a moderate inhibitor of HIV-1 reverse transcriptase and a weak inhibitor of HIV-1 protease. |
| Databáze: | OpenAIRE |
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