Analyzer-based imaging of spinal fusion in an animal model
| Autor: | Elisabeth Schültke, L A Allen, David Fiorella, L D Chapman, R C Beavis, Bernhard H.J. Juurlink, Michael Kelly, Zhong Zhong |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Spectrum analyzer Image quality medicine.medical_treatment Radiography Bone grafting Iliac crest Absorption Animal model Medicine Animals Radiology Nuclear Medicine and imaging Rats Wistar Palpation Radiological and Ultrasound Technology business.industry Decortication Rats medicine.anatomical_structure Spinal Fusion Spinal fusion Models Animal business Nuclear medicine Synchrotrons |
| Zdroj: | Physics in medicine and biology. 53(10) |
| ISSN: | 0031-9155 |
| Popis: | Analyzer-based imaging (ABI) utilizes synchrotron radiation sources to create collimated monochromatic x-rays. In addition to x-ray absorption, this technique uses refraction and scatter rejection to create images. ABI provides dramatically improved contrast over standard imaging techniques. Twenty-one adult male Wistar rats were divided into four experimental groups to undergo the following interventions: (1) non-injured control, (2) decortication alone, (3) decortication with iliac crest bone grafting and (4) decortication with iliac crest bone grafting and interspinous wiring. Surgical procedures were performed at the L5-6 level. Animals were killed at 2, 4 and 6 weeks after the intervention and the spine muscle blocks were excised. Specimens were assessed for the presence of fusion by (1) manual testing, (2) conventional absorption radiography and (3) ABI. ABI showed no evidence of bone fusion in groups 1 and 2 and showed solid or possibly solid fusion in subjects from groups 3 and 4 at 6 weeks. Metal artifacts were not present in any of the ABI images. Conventional absorption radiographs did not provide diagnostic quality imaging of either the graft material or fusion masses in any of the specimens in any of the groups. Synchrotron-based ABI represents a novel imaging technique which can be used to assess spinal fusion in a small animal model. ABI produces superior image quality when compared to conventional radiographs. |
| Databáze: | OpenAIRE |
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