Electrophysiological Studies in Thyroid Associated Orbitopathy: A Systematic Review

Autor:	Alvin L. Young, Kelvin K.L. Chong, Tiara W. U. Iao, An Ni Ling, Marten E. Brelen, Shi Song Rong
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Pediatrics medicine.medical_specialty Pathology Visual acuity genetic structures MEDLINE Visual Acuity lcsh:Medicine 030209 endocrinology & metabolism Eye Article Optic neuropathy 03 medical and health sciences 0302 clinical medicine Optic Nerve Diseases Electroretinography Medicine Humans Evoked potential lcsh:Science Multidisciplinary medicine.diagnostic_test business.industry Thyroid lcsh:R medicine.disease Graves Ophthalmopathy Study heterogeneity medicine.anatomical_structure P100 Latency 030221 ophthalmology & optometry Evoked Potentials Visual lcsh:Q medicine.symptom business
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-017-11998-0
Popis:	Dysthyroid optic neuropathy (DON) is the commonest cause of blindness in thyroid associated orbitopathy (TAO). While diagnosis remains clinical, objective tests for eyes with early or equivocal findings are lacking. Various electrophysiological studies (EPS) have been reported, yet the types and parameters useful for DON remain inconclusive. We performed a systematic literature search in MEDLINE, EMBASE and the Cochrane databases via the OVID platform up to August 20, 2017. 437 records were identified for screening and 16 original studies (1327 eyes, 787 patients) were eligible for review. Pattern visual evoked potential (pVEP) was the most frequently studied EPS. Eyes of TAO patients with DON showed delayed P100 latencies, decreased P100 amplitudes or delayed N75 latencies during pVEP, compared to those without or healthy controls. Due to study heterogeneity, no quantitative analysis was possible. This review highlights the most common type (pVEP) and useful parameters (P100 latency and amplitude) of EPS, and supports further research on them using standardized testing conditions.
Databáze:	OpenAIRE
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