Encapsulation of active pharmaceutical ingredients in lipid micro/nanoparticles for oral administration by spray-cooling
| Autor: | Eliana B. Souto, Paula Kiyomi Okuro, Aleksandra Zielińska, Fernando Eustáquio de Matos Junior, João Dias-Ferreira, Patrícia Severino, Amanda Cano, Carmen Silvia Fávaro-Trindade |
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| Přispěvatelé: | Universidade do Minho |
| Rok vydání: | 2021 |
| Předmět: |
oral drug delivery
Pharmaceutical Science Nanotechnology 02 engineering and technology Review Raw material lipid nanoparticles 030226 pharmacology & pharmacy Toxicological risk Congealing spray 03 medical and health sciences 0302 clinical medicine Pharmacy and materia medica Oral administration parasitic diseases INSUMOS FARMACÊUTICOS Micro nanoparticles Active ingredient Spray cooling Science & Technology spray cooling Chemistry spray chilling 021001 nanoscience & nanotechnology Controlled release 3. Good health RS1-441 congealing spray Lipid nanoparticles Spray chilling Oral drug delivery 0210 nano-technology |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Pharmaceutics, Vol 13, Iss 1186, p 1186 (2021) Pharmaceutics |
| Popis: | Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solvents (mostly associated to toxicological risk), and it can be applied for lipid raw materials as excipients of oral pharmaceutical formulations. The objective of this work was to revise and discuss the advances of spray cooling technology, with a greater emphasis on the development of lipid micro/nanoparticles to the load of active pharmaceutical ingredients for oral administration. This research was funded by the Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE), under the project reference UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020, granted to Eliana B. Souto. This work was also supported by the National Science Centre within the MINIATURA 4 for a single research activity carried out by Aleksandra Zieli ´nska (grant no: 2020/04/X/ST5/00789), and by the Institute of Human Genetics, Polish Academy of Sciences by the internal grant for the implementation of a single scientific activity. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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