Minimum information about animal experiments: supplier is also important
| Autor: | Luc Bauchet, Christian B. Brøchner, Monica Prieto, Manuel Gaviria, Henri Haton, Vincent Costalat, Nicolas Lonjon, Florence E. Perrin, Alain Privat |
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| Přispěvatelé: | Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Hamel, Christian, Physiopathologie et thérapie des déficits sensoriels et moteurs, Université Montpellier 2 - Sciences et Techniques (UM2)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurochirurgie [Hôpital Gui de Chauliac], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier], Service de neuroradiologie, Neuréva Inc.-INM, Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) |
| Rok vydání: | 2009 |
| Předmět: |
Animal Experimentation
Biomedical Research Computer science [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Sensory system 03 medical and health sciences Cellular and Molecular Neuroscience Animal.strain 0302 clinical medicine Control theory medicine Animals [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Rats Wistar Set (psychology) Spinal cord injury Spinal Cord Injuries ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Recovery of Function Anatomy Functional recovery medicine.disease Rats Disease Models Animal Vertebral canal [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroscience Research Journal of Neuroscience Research, Wiley, 2009, 87 (2), pp.403-407. ⟨10.1002/jnr.21871⟩ Journal of Neuroscience Research, Wiley, 2009, 87 (2), pp.403-7. ⟨10.1002/jnr.21871⟩ |
| ISSN: | 1097-4547 0360-4012 |
| DOI: | 10.1002/jnr.21871 |
| Popis: | International audience; It has now been established that functional recovery after spinal cord injury (SCI) depends on several parameters, including animal strain. Here we demonstrate that rats from the same strain (Wistar) but from two independent commercial suppliers present different motor, sensory, and autonomic outcomes after a standard model of SCI, the so-called compression model. Recovery is correlated with the extension of the lesion, and we show that the vertebral canal diameter varies between the two suppliers. To substantiate this point, we carried out another set of experiments, with the so-called contusion model, which requires bone ablation and thus whose extension is not related to vertebral canal diameter. We show that there is no difference between the two suppliers. The purpose of our communication is to alert researchers on how crucial it is to control experimental parameters as closely as possible and to establish a standard for animal experiment in order to avoid unexpected biases. |
| Databáze: | OpenAIRE |
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