Gait Impairment in a Rat Model of Focal Cerebral Ischemia
| Autor: | Joanna K. Huttunen, Jukka Jolkkonen, Kristina Kuptsova, Saara Parkkinen, Francisco J. Ortega, Ina M. Tarkka |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Article Subject business.industry Ischemia ta3141 medicine.disease ta3112 Surgery Preferred walking speed Gait (human) Gait impairment Physical medicine and rehabilitation Peripheral nerve injury Neuropathic pain medicine Neurology. Diseases of the nervous system cardiovascular diseases Neurology (clinical) RC346-429 business Spinal cord injury Stroke Research Article |
| Zdroj: | Stroke Research and Treatment Stroke Research and Treatment, Vol 2013 (2013) |
| ISSN: | 2042-0056 2090-8105 |
| DOI: | 10.1155/2013/410972 |
| Popis: | The availability of proper tests for gait evaluation following cerebral ischemia in rats has been limited. The automated, quantitative CatWalk system, which was initially designed to measure gait in models of spinal cord injury, neuropathic pain, and peripheral nerve injury, is said to be a useful tool for the study of motor impairment in stroke animals. Here we report our experiences of using CatWalk XT with rats subjected to transient middle cerebral artery occlusion (MCAO), during their six-week followup. Large corticostriatal infarct was confirmed by MRI in all MCAO rats, which was associated with severe sensorimotor impairment. In contrast, the gait impairment was at most mild, which is consistent with seemingly normal locomotion of MCAO rats. Many of the gait parameters were affected by body weight, walking speed, and motivation despite the use of a goal box. In addition, MCAO rats showed bilateral compensation, which was developed to stabilize proper locomotion. All of these interferences may confound the data interpretation. Taken together, the translational applicability of CatWalk XT in evaluating motor impairment and treatment efficacy remains to be limited at least in rats with severe corticostriatal infarct and loss of body weight. |
| Databáze: | OpenAIRE |
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