Importance of Early Absolute Lymphocyte Count After Allogeneic Stem Cell Transplantation: A Retrospective Study
| Autor: | M. Michalowski, Bruna Amorin, M.A. da Silva, Gustavo Brandão Fischer, E. Ottoni, Álvaro Macedo Laureano, B.S. Pitombeira, Lucia Mariano da Rocha Silla, Annelise Pezzi, Ayana Cavalcante da Paz, Letícia Baggio, Vanessa de Souza Valim, Lisandra Della Costa Rigoni, Liane Esteves Daudt, Maria Lúcia Scroferneker |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Time Factors Adolescent Lymphocyte medicine.medical_treatment Tumor cells Hematopoietic stem cell transplantation Disease-Free Survival Young Adult Predictive Value of Tests hemic and lymphatic diseases Internal medicine medicine Overall survival Humans Transplantation Homologous Lymphocyte Count Aged Retrospective Studies Transplantation Leukemia business.industry Hematopoietic Stem Cell Transplantation Absolute lymphocyte count Retrospective cohort study Middle Aged Survival Rate Treatment Outcome surgical procedures operative medicine.anatomical_structure Myelodysplastic Syndromes Immunology Female Surgery Stem cell business |
| Zdroj: | Transplantation Proceedings. 47:511-516 |
| ISSN: | 0041-1345 |
| Popis: | Early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (HSCT) is related to the prevention of serious infections and the clearing of residual tumor cells.We analyzed the absolute lymphocyte count at 20 (D+20) and 30 (D+30) days after HSCT in 100 patients with malignant hematologic diseases and correlated with the risk of transplant-related mortality, overall survival (OS), disease-free survival (DFS), nonrelapsed mortality (NRM), and risk of infection.Patients presenting with lymphocyte counts of300 × 103/μL on D+30 have a 3.76 times greater risk of death in100 days. Over a medium follow-up of 20 months OS, DFS, and NRM were similar between the groups.In our group of patients delayed lymphocyte recovery after HSCT was a predictor of early death post-HSCT. |
| Databáze: | OpenAIRE |
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