A prospective randomised study of the effect of nicardipine on ischaemic renal injury in renal allografts
| Autor: | M. L. Nicholson, Peter S. Veitch, P. R. F. Bell |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Graft Rejection Male Nephrology medicine.medical_specialty Adolescent Hypertonic Solutions Nicardipine Renal function Kidney chemistry.chemical_compound Double-Blind Method Renal injury Ischemia Risk Factors Internal medicine medicine Humans Prospective Studies Child Kidney transplantation Aged Transplantation Creatinine business.industry Organ Preservation Middle Aged Calcium Channel Blockers medicine.disease Kidney Transplantation Tissue Donors Delayed Graft Function Perfusion Exact test medicine.anatomical_structure chemistry Child Preschool Anesthesia Female business medicine.drug |
| Zdroj: | Transplant International. 9:51-56 |
| ISSN: | 1432-2277 0934-0874 |
| DOI: | 10.1111/j.1432-2277.1996.tb00852.x |
| Popis: | In a prospective double-blind trial, 127 kidneys were randomised to receive Eurocollins (n = 65) or Eurocollins plus nicardipine (n = 62) as a second flush solution at the time of organ retrieval. Delayed graft function occurred in 18 of 65 control kidneys (28%) and in 20 of 62 nicardipine kidneys (32%; P = 0.7, Fischer's exact test). The mean (SD) serum creatinine at 6 weeks was 197 (138) mumol/l in the Eurocollins group and 195 (159) mumol/l in the nicardipine group (P = 0.95). Eighteen recipients (28%) in the controlled Eurocollins group experienced a rejection episode in the first 6 weeks post-transplant compared to 17 (27%) in the nicardipine group (chi 2 with Yates' correction = 0.027; P = > 0.95). In this study, the addition of nicardipine to the kidney perfusion fluid did not have a beneficial effect on kidney function following transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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