Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons
| Autor: | Tina Hu, Michal Sharoni, Mohammad Nayal, Edward A. Waddell, Faith L.W. Liebl, Yonggang Zhang, Kaveesh Kutty, Ting Zhang, Cem Sahin, Wenhui Hu, Daniel R. Marenda, Mitchell D'Rozario |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Transcription Genetic Cellular differentiation Neurexin Synaptic Transmission Mice 0302 clinical medicine bHLH Basic Helix-Loop-Helix Transcription Factors Drosophila Proteins Promoter Regions Genetic lcsh:QH301-705.5 Genetics biology Behavior Animal Neurogenesis Cell Differentiation Cell biology Drosophila melanogaster Phenotype Gene Knockdown Techniques proneural daughterless Drosophila Protein Protein Binding endocrine system Neurite Cell Adhesion Molecules Neuronal Neuromuscular Junction Presynaptic Terminals Mitosis Proneural genes Motor Activity General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Neurites Animals Transcription factor TCF4 NMJ Pitt-Hopkins biology.organism_classification Axons schizophrenia 030104 developmental biology lcsh:Biology (General) Synapses Protein Multimerization 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports, Vol 15, Iss 2, Pp 386-397 (2016) |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2016.03.034 |
| Popis: | SummaryProneural proteins of the class I/II basic-helix-loop-helix (bHLH) family are highly conserved transcription factors. Class I bHLH proteins are expressed in a broad number of tissues during development, whereas class II bHLH protein expression is more tissue restricted. Our understanding of the function of class I/II bHLH transcription factors in both invertebrate and vertebrate neurobiology is largely focused on their function as regulators of neurogenesis. Here, we show that the class I bHLH proteins Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation. Our data indicate that Daughterless performs this function in part by restricting the expression of the cell adhesion molecule Neurexin. This suggests a role for these proteins outside of their established roles in neurogenesis. |
| Databáze: | OpenAIRE |
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