AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features
| Autor: | Susanne Schnittger, T Haferlach, Alexander Kohlmann, Wolfgang Kern, Hans-Ulrich Klein, H. Löffler, Ulrike Bacher, Williams Pm, Christian Ruckert, Claudia Haferlach, Martin Dugas |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Myeloid Biology MYST3 Translocation Genetic Immunophenotyping hemic and lymphatic diseases medicine Humans Gene Regulatory Networks RNA Messenger neoplasms In Situ Hybridization Fluorescence Aged Oligonucleotide Array Sequence Analysis Aged 80 and over Chromosome Aberrations Acute leukemia Reverse Transcriptase Polymerase Chain Reaction Gene Expression Profiling Cytogenetics Myeloid leukemia Chromosome Mapping Hematology Histone-Lysine N-Methyltransferase Middle Aged medicine.disease Prognosis Survival Rate Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Oncology Immunology Cytogenetic Analysis Cancer research Myeloid-Lymphoid Leukemia Protein Female Chromosomes Human Pair 16 Chromosomes Human Pair 8 |
| Zdroj: | Leukemia. 23(5) |
| ISSN: | 1476-5551 |
| Popis: | Balanced chromosomal rearrangements define distinct entities in acute myeloid leukemia (AML). Here, we present 13 AML cases with t(8;16)(p11;p13) with observed low incidence (13/6124 patients), but more frequent presentation in therapy-related AML than in de novo AML (7/438 versus 6/5686, P=0.00001). Prognosis was poor with median overall survival of 4.7 months. Cytomorphology was characterized by parallel positive myeloperoxidase and non-specific esterase staining, therefore, French-American-British (FAB)-classification was impossible and origin of the AML with t(8;16) from an early stem cell with myeloid and monoblastic potential is hypothesized. Erythrophagocytosis was observed in 7/13 cases. Using gene expression profiling on 407 cases, patients with t(8;16) were compared to AML FAB subtypes with normal karyotype. Principal component analyses demonstrated that AML with t(8;16) were distinct from FAB subtypes M1, M4, M5a/b. When further compared to AML showing balanced rearrangements, that is, current WHO categories t(15;17), t(8;21), inv(16) and t(11q23)/MLL, AML with t(8;16) cases were clustered close to t(11q23)/MLL sharing commonly expressed genes. Subsequently, a pairwise comparison discriminated AML with t(8;16) from AML with t(11q23)/MLL, thus defining a highly unique signature for AML with t(8;16). In conclusion, AML with t(8;16) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features and is a specific subtype of AML. |
| Databáze: | OpenAIRE |
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