Clinical outcome in patients with acute coronary syndrome and outward remodeling is associated with a predominant inflammatory response
| Autor: | Mariano Ledesma-Velasco, Silvestre Armando Montoya-Guerrero, Karina Chávez-Rueda, María Victoria Legorreta-Haquet, Alejandra Madrid-Miller, Luis Chávez-Sánchez, Arturo Abundes Velazco, Gabriela Borrayo-Sánchez, Guillermo Careaga-Reyna, Francisco Blanco-Favela |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome medicine.medical_treatment Short Report Inflammation Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology Angina Restenosis Internal medicine Intravascular ultrasound medicine Humans Aged Medicine(all) medicine.diagnostic_test Biochemistry Genetics and Molecular Biology(all) business.industry Unstable angina Low-density lipoprotein Percutaneous coronary intervention General Medicine Middle Aged Flow Cytometry medicine.disease Cardiology Female medicine.symptom business |
| Zdroj: | BMC Research Notes |
| ISSN: | 1756-0500 |
| DOI: | 10.1186/1756-0500-7-669 |
| Popis: | Background Pro-inflammatory molecules and low-density lipoproteins play essential roles in the atherosclerosis. The aim of our study was to establish an association among the cytokines secreted by peripheral blood mononuclear cells and the serum concentration in patients with unstable angina and coronary outward remodeling before and after percutaneous coronary intervention. The clinical and coronary responses were evaluated 6 months after the procedure. Findings Twenty-two patients with unstable angina were evaluated prior to after percutaneous coronary intervention and 6 months after procedure by coronary intravascular ultrasound. Eleven of the patients had recurrent angina, while 9 presented restenosis and an increase in the percentage of total plaque area. These 11 patients displayed higher levels of C-reactive protein than those without coronary events (1.27 vs. 0.43 mg/dl, respectively; p = 0.029) and a tendency to increase levels of interleukin (IL)-8 and transforming growth factor-β1, but lower levels of IL-10 (52.09 vs. 141.5 pg/ml, respectively; p = 0.035). Activated peripheral blood mononuclear cells from patients with restenosis presented higher levels of proliferation, CD86 expression and higher IL-1, and increased IL-10 compared to those in patients without restenosis. Conclusions Patients with unstable angina and coronary outward remodeling who displayed a pro-inflammatory response experienced recurrent coronary events and an increased percentage of total plaque area. In contrast, better outcomes were observed in patients with anti-inflammatory responses. This response could be secondary to low-density lipoproteins. |
| Databáze: | OpenAIRE |
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