All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery

Autor: Sh Moon Seung-Ho Moon, J-H Lee, Kr Lee Kyu-Ri Lee, Yuhan Lee, Jw Cheon Jin-Woo Cheon, Tg Park Tae Gwan Park
Rok vydání: 2009
Předmět:
Zdroj: Angewandte Chemie (International ed. in English). 48(23)
ISSN: 1521-3773
Popis: Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
Databáze: OpenAIRE