All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery
| Autor: | Sh Moon Seung-Ho Moon, J-H Lee, Kr Lee Kyu-Ri Lee, Yuhan Lee, Jw Cheon Jin-Woo Cheon, Tg Park Tae Gwan Park |
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| Rok vydání: | 2009 |
| Předmět: |
Nanotechnology
Gene delivery Transfection Ferric Compounds Catalysis Magnetics Cell Line Tumor Neoplasms medicine Gene silencing Moiety Humans Gene Silencing RNA Small Interfering Fluorescent Dyes medicine.diagnostic_test Chemistry Magnetic resonance imaging General Chemistry General Medicine equipment and supplies Fluorescence Magnetic Resonance Imaging Spectrometry Fluorescence Gene Knockdown Techniques Drug delivery Magnetic nanoparticles Nanoparticles Molecular imaging human activities Oligopeptides |
| Zdroj: | Angewandte Chemie (International ed. in English). 48(23) |
| ISSN: | 1521-3773 |
| Popis: | Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications. |
| Databáze: | OpenAIRE |
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