Indoor Air Pollution and Susceptibility to Tuberculosis Infection in Urban Vietnamese Children

Autor: Robert J. Blount, Mark R. Segal, Ha Phan, Joseph Zabner, Emma M. Stapleton, Michael Zavala, Trang D Trinh, Nguyen Viet Nhung, Hai Dang, Payam Nahid, Alejandro P. Comellas, John R. Balmes, Cindy Merrifield
Rok vydání: 2021
Předmět:
Male
Urban Population
Respiratory System
smoking water pipes
Critical Care and Intensive Care Medicine
Medical and Health Sciences
Indoor air quality
Odds Ratio
2.2 Factors relating to the physical environment
Cooking
Aetiology
Child
Lung
Built environment
Vehicle Emissions
Pediatric
Infectious Diseases
Vietnam
Air Pollution
Indoor
Child
Preschool
language
Female
Disease Susceptibility
Pulmonary and Respiratory Medicine
Tuberculosis
Vietnamese
Southeast asian
Risk Assessment
tobacco smoke pollution
Rare Diseases
Asian People
Latent Tuberculosis
Clinical Research
Air Pollution
Environmental health
Smoking Water Pipes
medicine
Humans
Indoor
Preschool
business.industry
Editorials
medicine.disease
built environment
language.human_language
Health Effects of Indoor Air Pollution
Good Health and Well Being
Case-Control Studies
motorcycles
Tobacco Smoke Pollution
business
Zdroj: American journal of respiratory and critical care medicine, vol 204, iss 10
American Journal of Respiratory and Critical Care Medicine
ISSN: 1535-4970
1073-449X
Popis: Rationale: The Southeast Asian tuberculosis burden is high, and it remains unclear if urban indoor air pollution in this setting is exacerbating the epidemic. Objectives: To determine the associations of latent tuberculosis with common urban indoor air pollution sources (secondhand smoke, indoor motorcycle emissions, and cooking) in Southeast Asia. Methods: We enrolled child household contacts of patients with microbiologically confirmed active tuberculosis in Vietnam, from July 2017 to December 2019. We tested children for latent tuberculosis and evaluated air pollution exposures with questionnaires and personal aerosol sampling. We tested hypotheses using generalized estimating equations. Measurements and Main Results: We enrolled 72 patients with tuberculosis (27% with cavitary disease) and 109 of their child household contacts. Latent tuberculosis was diagnosed in 58 (53%) household contacts at baseline visit. Children experienced a 2.56-fold increased odds of latent tuberculosis for each additional household member who smoked (95% confidence interval, 1.27-5.16). Odds were highest among children exposed to indoor smokers and children
Databáze: OpenAIRE
Externí odkaz: