Translating U-500R Randomized Clinical Trial Evidence to the Practice Setting: A Diabetes Educator/Expert Prescriber Team Approach
Autor: | Arti Bhan, Wael Eid, Jeffrey A. Jackson, April D. Taylor, Paula M. Bergen, Davida F. Kruger |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male medicine.medical_specialty Tool Chest Endocrinology Diabetes and Metabolism Alternative medicine MEDLINE 030209 endocrinology & metabolism Type 2 diabetes Health Professions (miscellaneous) law.invention Translational Research Biomedical 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Patient Education as Topic law Multidisciplinary approach Insulin Regular Human medicine Humans Hypoglycemic Agents 030212 general & internal medicine Dosing Intensive care medicine Glycemic Randomized Controlled Trials as Topic Patient Care Team Dose-Response Relationship Drug business.industry Health Educators medicine.disease Clinical trial Diabetes Mellitus Type 2 Physical therapy Female Insulin Resistance business |
Zdroj: | The Diabetes Educator |
ISSN: | 1554-6063 |
Popis: | Purpose The purpose of this article is to provide recommendations to the diabetes educator/expert prescriber team for the use of human regular U-500 insulin (U-500R) in patients with severely insulin-resistant type 2 diabetes, including its initiation and titration, by utilizing dosing charts and teaching materials translated from a recent U-500R clinical trial. Conclusions Clinically relevant recommendations and teaching materials for the optimal use and management of U-500R in clinical practice are provided based on the efficacy and safety results of and lessons learned from the U-500R clinical trial by Hood et al, current standards of practice, and the authors’ clinical expertise. This trial was the first robustly powered, randomized, titration-to-target trial to compare twice-daily and three-times-daily U-500R dosing regimens. Modifications were made to the initiation and titration dosing algorithms used in this trial to simplify dosing strategies for the clinical setting and align with current glycemic targets recommended by the American Diabetes Association. Leveraging the expertise, resources, and patient interactions of the diabetes educator who can provide diabetes self-management education and support in collaboration with the multidisciplinary diabetes team is strongly recommended to ensure patients treated with U-500R receive the timely and comprehensive care required to safely and effectively use this highly concentrated insulin. |
Databáze: | OpenAIRE |
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