A Pathoconnectome of Early Neurodegeneration
| Autor: | Kevin Rapp, Alexis R. Houser, James R. Anderson, Crystal Sigulinsky, Hope Morrison, Jessica C. Garcia, Carl B. Watt, Jia-Hui Yang, Daniel Emrich, Rebecca L. Pfeiffer, Jeebika Dahal, Robert E. Marc, Bryan W. Jones |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Neurite sprouting Connectomics Retina Artificial neural network Neurodegeneration Biology medicine.disease Network topology Photoreceptor degeneration 3. Good health 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Neuron Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| DOI: | 10.1101/2020.01.31.929265 |
| Popis: | Connectomics has demonstrated that synaptic networks and their topologies are precise and directly correlate with physiology and behavior. The next extension of connectomics is pathoconnectomics: to map neural network synaptology and circuit topologies corrupted by neurological disease in order to identify robust targets for therapeutics. In this report, we characterize the first pathoconnectome, in this case, generated from a retina with photoreceptor degeneration. We observe aberrant connectivity in the rod-network pathway and novel synaptic connections deriving from neurite sprouting. These observations reveal principles of neuron responses to the loss of network components and can be extended to other neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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