Enhancing functional abilities and cognitive integration of the lower limb prosthesis
| Autor: | Marko Bumbasirevic, Bogdan Mijovic, Asgeir Alexandersson, Pavle Mijović, Arthur Hiairrassary, Giacomo Valle, Dario Bortolotti, Atli Örn Sverrisson, Alessandra Pedrocchi, Paul Čvančara, David Guiraud, Aleksandar Lesic, Thomas Stieglitz, Francesco Maria Petrini, Jean-Louis Divoux, Stanisa Raspopovic, Igor Popovic, Federica Barberi, Silvestro Micera, Knut Lechler |
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| Přispěvatelé: | Center for Neuroprosthetics [Geneva] (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Fondation Bertarelli Chair inTranslational Neuroscience and Neuroengineering [Lausanne], Center for Neuroprosthetics and Institute of Bioengineering, EPFL.-Fondation Bertarelli, The BioRobotics Institute, Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Department of Electronics, Information, and Bioengineering [Milano] (DEIB), Politecnico di Milano [Milan] (POLIMI), School of Medecine [Belgrade], University of Belgrade [Belgrade], University of Freiburg [Freiburg], Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), mBrainTrain [Belgrade], Össur hf [Copenhagen], AXONIC - OBELIA dept, MXM-Laboratoires de Techologies Médicales, Special Hospital for Rehabilitation and Orthopaedic Prosthetics [Belgrade], Department of Microsystems Engineering [Freiburg] (IMTEK), Department of Health Sciences and Technology [ETH Zürich] (D-HEST), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Ecole Polytechnique Fédérale de Lausanne (EPFL)-Fondation Bertarelli, Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
leg medicine.medical_specialty sensory feedback Neuroprosthetics Knee Joint medicine.medical_treatment media_common.quotation_subject [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Sensory system Artificial Limbs system Prosthesis Design neuroprostheses Prosthesis [SPI.AUTO]Engineering Sciences [physics]/Automatic 03 medical and health sciences walking 0302 clinical medicine Physical medicine and rehabilitation Cognition Amputees discharge Perception amputation Activities of Daily Living medicine [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Humans knee-joint media_common Haptic technology gait symmetry Proprioception Work (physics) General Medicine 3. Good health body regions 030104 developmental biology Lower Extremity Psychology 030217 neurology & neurosurgery performance |
| Zdroj: | Science Translational Medicine, 11 (512) Science Translational Medicine Science Translational Medicine, American Association for the Advancement of Science, 2019, 11 (512), pp.eaav8939. ⟨10.1126/scitranslmed.aav8939⟩ Science Translational Medicine, 2019, 11 (512), pp.eaav8939. ⟨10.1126/scitranslmed.aav8939⟩ |
| ISSN: | 1946-6234 1946-6242 |
| DOI: | 10.1126/scitranslmed.aav8939⟩ |
| Popis: | International audience; Lower limb amputation (LLA) destroys the sensory communication between the brain and the external world during standing and walking. Current prostheses do not restore sensory feedback to amputees, who, relying on very limited haptic information from the stump-socket interaction, are forced to deal with serious issues: the risk of falls, decreased mobility, prosthesis being perceived as an external object (low embodiment), and increased cognitive burden. Poor mobility is one of the causes of eventual device abandonment. Restoring sensory feedback from the missing leg of above-knee (transfemoral) amputees and integrating the sensory feedback into the sensorimotor loop would markedly improve the life of patients. In this study, we developed a leg neuroprosthesis, which provided real-time tactile and emulated proprioceptive feedback to three transfemoral amputees through nerve stimulation. The feedback was exploited in active tasks, which proved that our approach promoted improved mobility, fall prevention, and agility. We also showed increased embodiment of the lower limb prosthesis (LLP), through phantom leg displacement perception and questionnaires, and ease of the cognitive effort during a dual-task paradigm, through electroencephalographic recordings. Our results demonstrate that induced sensory feedback can be integrated at supraspinal levels to restore functional abilities of the missing leg. This work paves the way for further investigations about how the brain interprets different artificial feedback strategies and for the development of fully implantable sensory-enhanced leg neuroprostheses, which could drastically ameliorate life quality in people with disability. |
| Databáze: | OpenAIRE |
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