The distribution of elements in the tissues of Watanabe Heritable Hyperlipidemic Rabbits
| Autor: | N. Krari, Bled F, Girault M, P. Allain, Balanant Y, D. Chaleil |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Hypercholesterolemia chemistry.chemical_element Spleen Zinc Biochemistry Inorganic Chemistry chemistry.chemical_compound medicine.artery Internal medicine medicine Animals Tissue Distribution Receptor Aorta Kidney biology Cholesterol Biochemistry (medical) General Medicine Elements medicine.anatomical_structure Endocrinology chemistry Low-density lipoprotein biology.protein Rabbits Ceruloplasmin |
| Zdroj: | Biological trace element research. 19(3) |
| ISSN: | 0163-4984 |
| Popis: | A deficiency or an excess of some elements in the diet is reported to modify the concentration of cholesterol in plasma, and, conversely, a reduction of cholesterol in the diet decreases zinc in plasma. We have studied the distribution of elements Na, K, Ca, Mg, Fe, Cu, Zn, S, P, and Mn in the tissues, plasma, heart, aorta, lung, liver, spleen, kidney, thymus, and brain of New Zealand White rabbits (NZW) and of Watanabe Heritable Hyperlipidemic rabbits (WHHL). The WHHL rabbits had a massive hypercholesterolemia (7.45 ± 1.2 g/L) induced by a lack of liver low density lipoprotein receptors. The concentrations of elements in the tissues of the control NZW rabbits were very similar to those found in the normal rat. In WHHL, compared to NZW, besides the very important increase of total phosphorus in plasma explained by the augmentation of phospholipids, there was an increase of plasma copper (+ 44%) and zinc (+ 36%). The other noticeable changes were an increase of iron in heart (+ 19%), sulfur, and zinc in liver (+ 15% and +18%). The other changes observed in WHHL rabbits were, besides the increase of ceruloplasmin, the increase of vit E (+ 468%) and MDA (+ 62%). In conclusion, despite a massive increase of lipids in plasma, there was no major disturbance of element distribution in WHHL rabbits. |
| Databáze: | OpenAIRE |
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