Cardiometabolic risk among HIV-POSITIVE Ugandan adults: prevalence, predictors and effect of long-term antiretroviral therapy
| Autor: | Ivan Kasamba, Ivan Namakoola, Paula Munderi, Joseph Lutaakome, Billy N. Mayanja, Pontiano Kaleebu, Tino Salome, Patrick Kazooba |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty obesity hypertension HIV cardiometabolic dyslipidemia long-term ART hypertension obesity Adolescent Anti-HIV Agents HIV Infections 030204 cardiovascular system & hematology long-term ART Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Metabolic Diseases Risk Factors Internal medicine medicine Prevalence Humans Uganda 030212 general & internal medicine Prospective Studies Young adult Prospective cohort study Abdominal obesity Framingham Risk Score business.industry Research dyslipidemia Age Factors HIV General Medicine Middle Aged medicine.disease Obesity Lipids Regimen Cardiovascular Diseases Multivariate Analysis Physical therapy cardiometabolic Linear Models Female medicine.symptom business Dyslipidemia Cohort study |
| Zdroj: | The Pan African Medical Journal Pan African Medical Journal; Vol 27, No 1 (2017) |
| ISSN: | 1937-8688 |
| Popis: | Introduction: We investigated the prevalence, predictors of and effect of Antiretroviral Therapy (ART) regimen on cardiometabolic risk among HIV-positive Ugandan adults at enrolment into a prospective cohort to study the Complications of Long-Term ART (CoLTART).Methods: We collected data on cardiometabolic risk factors including dyslipidemia, hypertension, hyperglycemia, obesity and calculated the mean atherogenic index for Plasma (AIP) and 10 year Framingham risk score (FHS). Exposures were: ART regimen, duration on ART, demographic, socio-economic, behavioral, and life-style factors including smoking, physical activity and diet (including fruit and vegetables consumption).Results: We enrolled 1024 participants, 65% female, mean age was 44.8 years (SD 8.0) and median duration on ART was 9.4 years (IQR 6.1-9.8). The prevalence of abdominal obesity was 52.6%, BMI≥25 kg/m2 -26.1%, hypertension-22.6%, high AIP-31.3% and FHS above 10% was 16.6%. The prevalence of low High Density Lipoprotein (HDL) was 37.5%, high Total cholesterol (Tc)-30.2%, high Low Density Lipoprotein (LDL) -23.6%, high Triglycerides (TG)-21.2%, low physical activity-46.4% and alcohol consumption 26.4%. In multivariate linear regression analyses, increasing age was associated with higher mean Tc, HDL, LDL, FHS (P10% compared to the non PI regimen.Conclusion: ART increases cardiometabolic risk. Integration of routine assessment for cardiometabolic risk factors and preventive interventions into HIV care programs in resource-limited settings is recommended.Keywords: HIV, cardiometabolic, dyslipidemia, long-term ART, hypertension, obesity |
| Databáze: | OpenAIRE |
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